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Approximately three thousand years before the Commonwealth of Vaults came to be, a technologically advanced civilization known as The Precursors wandered Konis. They lived in walled and mostly isolated city-states, much akin to the Vaults most Konians live in today, and would often battle each other over turf or resources - in fact, they fought so often that their Kings were desperate for alternative ways to slaying his rival's men. Thus, over the span of centuries, the scientific Seers went to extraordinary lengths to invent the most gruesome biological weapons known to mankind: viruses, toxic bombs and poisons meant to look like beer - yet what remained awfully popular throughout the ages were genetically modified animals of war, solely called into life to battle and kill their foes.
Even ages after the re-discovery of this vicious phenomenon, many scholars are still in the dark about which animals have been included into the cocktail of traits that the Therion strain consists of.